The Enhancement of Chitosan in Transdermal Drug Delivery Processes

• Main Authors: Chia-Wei Hsu, 許嘉偉
• Other Authors: 張厚謙
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/46302455348288782107

碩士 === 國立中興大學 === 化學工程學系所 === 99 === The stratum corneum layer is viewed as the most significant permeation resistance in transdermal drug delivery process. Physical and chemical enhancements are commonly used to reduce the permeation barrier for drug molecular and thus increase the efficiency of transdermal absorption. The purpose of the research is to evaluate the transdermal drug delivery enhancement capacity of chitosan with a various combinations of molecular weights and concentrations. Resorcinol and thermosensitive copolymers were chosen as model drug and dug carrier. Different gels were prepared with Medium molecular weight chitosan (MC), Low molecular weight chitosan (LC), respectively as enhancer, and the control was chosen to be with no enhancer. In vitro permeation studies were carried out using Franz-diffusion cells and the analytical model was employed to fit the effective permeation coefficient with experiment data. The result showed that the drug permeation coefficient decreases as the molecular weight of chitosan increases. The permeability was found to have no positive non negative correlation with the concentration of chitosan. The local maximum of permeabilities were appeared at 0.005g/ml and 0.0075g/ml for MC/Poloxamer and LC/Poloxamer respectively.