Development to increase anticancer activity of Baicalein and Gemcitabine by multifunctional solid lipid nanoparticle

碩士 === 高雄醫學大學 === 藥學研究所 === 99 === Baicalein, one of the flavonoids. It has been use as Traditional Chinese medicines and had been recently recognized as a new source of anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy and to ameliorate the side effects of cance...

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Main Authors: Tzu-Chin Weng, 翁子晉
Other Authors: Yi-Hung Tsai
Format: Others
Language:zh-TW
Published: 2011
Online Access:http://ndltd.ncl.edu.tw/handle/37466367602290477230
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spelling ndltd-TW-099KMC055510332015-10-13T20:37:29Z http://ndltd.ncl.edu.tw/handle/37466367602290477230 Development to increase anticancer activity of Baicalein and Gemcitabine by multifunctional solid lipid nanoparticle 研發增加Baicalein和Gemcitabine抗癌活性的多功能固態脂質奈米微粒 Tzu-Chin Weng 翁子晉 碩士 高雄醫學大學 藥學研究所 99 Baicalein, one of the flavonoids. It has been use as Traditional Chinese medicines and had been recently recognized as a new source of anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy and to ameliorate the side effects of cancer chemotherapies. Scutellaria baicalensis is one of the most popular and multi-purpose herb used in China traditionally for treatment of inflammation, hypertension, cardiovascular diseases, and bacterial and viral infections. We try to combine with another antitumor therapy drug, Gemicitabine. Gemcitabine1(2-deoxy-2, 2 -difluorocytidine, 2, 2 - difluorodeoxycytidine) is a pyrimidine analog that is proven to be active against a variety of solid tumors. It is widely used in the treatment of cancers of pancreas, lung, breast, bladder, kidney and biliary tract either singly or in combination with other cytotoxic agents. In our research, we found that when Baicalein combine with gemcitabine at specific ratio, it’s effective to inhibit the tumor cell proliferation. Besides, we try to encapsulate these two drug with a multifunctional solid lipid nanoparticle, with the function of anti-oxidation and carrying-charge and with the PEG agent for increase the circulation time of formulation , and the target receptor of folic acid-F68 and the temperature- sensitive property. After modify of these functions, we also analyze the physical characterization of the formulations, and the in vitro release profile of two drugs at different temperatures, and the cell analysis of the solution-type and SLN-type. In the releade profile, the formulation A5 had release about 80% in one hour and the formulation had not significant release than A5. In the cell analysis, the formulation with the multi-function modified had better tumor inhibition than the original formulation. With these functions of formulations, we try to enhance the anti-tumor effect of the cell line of A549. Yi-Hung Tsai 蔡義弘 2011 學位論文 ; thesis 111 zh-TW
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description 碩士 === 高雄醫學大學 === 藥學研究所 === 99 === Baicalein, one of the flavonoids. It has been use as Traditional Chinese medicines and had been recently recognized as a new source of anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy and to ameliorate the side effects of cancer chemotherapies. Scutellaria baicalensis is one of the most popular and multi-purpose herb used in China traditionally for treatment of inflammation, hypertension, cardiovascular diseases, and bacterial and viral infections. We try to combine with another antitumor therapy drug, Gemicitabine. Gemcitabine1(2-deoxy-2, 2 -difluorocytidine, 2, 2 - difluorodeoxycytidine) is a pyrimidine analog that is proven to be active against a variety of solid tumors. It is widely used in the treatment of cancers of pancreas, lung, breast, bladder, kidney and biliary tract either singly or in combination with other cytotoxic agents. In our research, we found that when Baicalein combine with gemcitabine at specific ratio, it’s effective to inhibit the tumor cell proliferation. Besides, we try to encapsulate these two drug with a multifunctional solid lipid nanoparticle, with the function of anti-oxidation and carrying-charge and with the PEG agent for increase the circulation time of formulation , and the target receptor of folic acid-F68 and the temperature- sensitive property. After modify of these functions, we also analyze the physical characterization of the formulations, and the in vitro release profile of two drugs at different temperatures, and the cell analysis of the solution-type and SLN-type. In the releade profile, the formulation A5 had release about 80% in one hour and the formulation had not significant release than A5. In the cell analysis, the formulation with the multi-function modified had better tumor inhibition than the original formulation. With these functions of formulations, we try to enhance the anti-tumor effect of the cell line of A549.
author2 Yi-Hung Tsai
author_facet Yi-Hung Tsai
Tzu-Chin Weng
翁子晉
author Tzu-Chin Weng
翁子晉
spellingShingle Tzu-Chin Weng
翁子晉
Development to increase anticancer activity of Baicalein and Gemcitabine by multifunctional solid lipid nanoparticle
author_sort Tzu-Chin Weng
title Development to increase anticancer activity of Baicalein and Gemcitabine by multifunctional solid lipid nanoparticle
title_short Development to increase anticancer activity of Baicalein and Gemcitabine by multifunctional solid lipid nanoparticle
title_full Development to increase anticancer activity of Baicalein and Gemcitabine by multifunctional solid lipid nanoparticle
title_fullStr Development to increase anticancer activity of Baicalein and Gemcitabine by multifunctional solid lipid nanoparticle
title_full_unstemmed Development to increase anticancer activity of Baicalein and Gemcitabine by multifunctional solid lipid nanoparticle
title_sort development to increase anticancer activity of baicalein and gemcitabine by multifunctional solid lipid nanoparticle
publishDate 2011
url http://ndltd.ncl.edu.tw/handle/37466367602290477230
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