Palladium-Catalyzed Allylation of Aminonaphthalenes with Allylic Acetates in PEG-H2O System

• Main Authors: Chun-Jen Shih, 石淳仁
• Other Authors: Shyh-Chyun Yang
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/60558606970930392875

碩士 === 高雄醫學大學 === 藥學研究所 === 99 === The synthetic utility of transition-metal catalyzed allylic alkylation has been demonstrated since its discovery nearly thirty years age. Allyl amines are an important class of compounds not only due to their utility as intermediates in organic synthesis but also because of their physiological properties and their presence in several natural products. The palladium-catalyzed allylation has been studied extensively as an efficient and highly stereo- and chemoselective method for C-C, C-N, and C-O bond formation. Polyethylene glycol was air stable, nontoxic, inexpensive and environmentally friendly. It is important in green chemistry. The Pd(OAc)2-H2O-PEG system are impressive activating for a wide range of substrates. Therefore, palladium catalyzed reactions with PEG has been carried out. Herein, we reported the allylation of aminonaphthalenes with allylic acetates in PEG-H2O in the presence of a catalytic amount of palladium. N-allylation of aminonaphthalene compounds was achieved.