| Summary: | 碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 99 === Zolpidem, a non-benzodiazepine sedative-hypnotic is currently used in medication to treat patients who suffer from insomnia and anxiety. In this master thesis, a new synthetic method of zolpidem analogues was described. 6-Methyl-2-p-tolyimidazo[1,2-a]pyridine which was prepared from 2-amino-5-methyl-pyridine with α-bromoacetophenone was used to react with iodine to yield 3-iodo-6-methyl-2-p-tolyimidazo[1,2-a] pyridine in good yields. Subsequently, the obtained iodoimidazopyridine was used to react with various alkyl acrylate to undergo the Heck reaction to give olefinic ester analogues of zolpidem (I) in good yields. Moreover, the given olefinic ester analogues (I) were saturated with hydrogen in the presence of Pd/C to yield alkyl ester analogues of zolpidem (II). All zolpidem analogues prepared in this thesis are new compounds, and their sedative-hypnotic activities are currently in progress.
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