The Studies of Serum Vitamin D Levels in Type 1 and Type 2 Diabetes Mellitus Patients

• Main Authors: Hsing-Cheng Tseng, 曾幸徵
• Other Authors: Bai-Hsiun Chen
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/75358107856425985793

碩士 === 高雄醫學大學 === 醫學研究所 === 99 === Except rickets in children and osteomalasia in adults, vitamin D deficiency may also related cancer, cardiovascular disease, diabetes and multiple sclerosis in human. There were controversial results of serum vitamin D levels in type 1 and type 2 diabetes patients and there were still no previous literatures concerning serum vitamin D levels in diabetes patients by using liquid chromatography tandem mass spectrometry to differentiate the possible source of vitamin d deficiency. We investigated Chinese serum specimens from 56 type 1 diabetes and 41 type 2 diabetes patients from Department of Pediatrics and Division of Endocrinology, Department of Internal Medicine, Kaohsiung Medical University Hospital outpatient clinics. Forty-four and twenty-eight non-diabetes age matched Chinese outpatients and volunteer in Department of Physical Examination of the same hospital were enrolled as type 1 and type 2 diabetes control groups, respectively. All participants in this study gave their informed consent which was approved by The Ethic Committee of our hospital. Serum 25(OH)D2 and 25(OH)D3 levels were measured with liquid chromatography tandem mass spectrometry. We found that our type 1 diabetes patients had significantly higher serum 25(OH)D and 25(OH) D3 levels than that of control groups. (p=0.002, 0.002, respectively). Type 2 diabetes patients also had significantly higher serum 25(OH) D3 levels than that of control groups (p=0.013, 0.012, respectively). There were no significant difference of serum 25(OH) D2 levels between type 1, type 2 diabetes and control groups. Our study revealed that 19.6% of type 1 diabetes patients were 25(OH)D insufficient (< 30 ng/mL) and 7.1% were 25(OH)D deficient. In type 2 diabetes patients, only 2.4% were 25(OH)D insufficient and none was 25(OH)D deficient. There were no correlation between serum calcium levels and 25(OH)D levels in type 1 and type 2 diabetes patients. There were also no correlation between serum 25(OH)D levels and HbA1C levels in type 1 and type 2 diabetes patients. In conclusion, the relationship between type 1, type 2 diabetes and serum 25(OH)D levels still needs further clarification.