Quality of Life and Survival Analysis Among Colorectal Cancer Surgery Patients：A longitudinal long-term study

• Main Authors: Po-Ying Chen, 陳柏穎
• Other Authors: Hon-Yi Shi
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/67021855237115465440

碩士 === 高雄醫學大學 === 醫務管理學研究所 === 99 === Purpose： In this study, we took patients with colorectal cancer surgery to do long-term longitudinal study. At first, we evaluate changing trend of patients and influencing factors after colorectal cancer surgery, and then, we discuss the relationship of important factors that influence patients’ survival with colorectal cancer surgery. Last, we compare the improvement of quality of life in different countries. Also, we expect that the results of this study could be a reference for clinical units. Method： This prospective study started from October 2008 to March 2000. We collected 104 patients who accepted colorectal cancer surgery. All patients in this research were traced 2 years at least. We use SF-36 and FACT-C(Functional Assessment of Chronic Therapy-Cancer) as our tools to measure patients’ quality of life. In addition, the methods included Effect Size (ES), Bootstrapping methods and GEE that can evaluate change of patients’ quality of life at different time points and important factors. Finally, we use Cox Regression to find the important factors of patients’ survival. Result： In the SF-36, the result showed the significant improvement (P <0.05)on physical function, emotional role limitations, and mental health at 3 months; the significant improvement (P <0.05) on limited role of physiological functions at 1 year; the significant improvement (P <0.05) on painful situation, dynamic conditions, mental health ,and general health at 2 year. In the FACT-C, the result showed the significant improvement (P <0.05)on social family function, emotional stability, and colorectal cancer-related matters at 1 months; the significant improvement (P <0.05) on physical health, clinical trials, general function evaluation, and overall quality of life assessment at 2 year. In addition, the result showed that gender, age, smoking, preoperative treatment, 30 days after readmission, tumor stage, tumor location are significant factors; age, 30-day readmission, tumor stage, emotional function dimension, physical pain, and physical health at preoperative are the significant factors of patients’ survival. Conclusion： The colorectal cancer patients have improved at 3 months and 2 years. With the comparison between two questionnaires, the study can measure the improvement trend of patients. Moreover, the preoperative status is also the most important factor. Therefore, we suggest the colorectal cancer patients should accept treatment as quickly as possible and clinical units should establish an integral care system to provide patients with a reference and educate patients. It will reduce mortality and improve quality of life.