| Summary: | 碩士 === 中原大學 === 生物科技研究所 === 99 === The metabolic syndrome (MS) is defined as a cluster of metabolic disorders in the person. Many studies shown MS caused an increased risk for type 2 diabetes mellitus and cardiovascular disease. The objective of this study is to develop health foods which can prevent the prevalence of MS.
In this study the ability of glucose uptake on 3T3-L1 adipocytes was used to find the potential food of MS preventing effect. We screened six food extracts, including licorice, green algae, roselle, cinnamon, chicory and fermented soy product. The data shown that the licorice, green algae and roselle extracts can increase the glucose uptake by the adipocytes. The effects of green algae and roselle on ameliorating MS were further evaluated by the animal model. Male Sprague-Dawley rats were divided into four groups: group basal (B), fed with normal chow diet ; group control (C), fed with 60% high fructose diet alone ; group green algae (G), fed with 60% high fructose diet plus 0.8% green algae extracts ; group roselle (R), fed with 60% high fructose diet plus 1% roselle extracts. The study lasted for 10 weeks. Blood pressure, fasting plasma glucose, insulin, triglyceride, total cholesterol and oral glucose tolerance tests (OGTT) were assayed.
The data shown that group C had higher abdominal fat mass, blood pressure, plasma triglyceride and total cholesterol as comparing with group B, indicating that high-fructose diet increased risks of metabolic syndrome. In group G, abdominal fat mass, systolic blood pressure, fasting plasma triglyceride and insulin sensitivity were improved as comparing with the group C. And compared to group C, the group R had lower systolic blood pressure, oxidative stress, GOT and higher insulin sensitivity. The results suggested that green algae and roselle may prevent metabolic syndrome.
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