| Summary: | 碩士 === 中山醫學大學 === 公共衛生學系碩士班 === 99 === Study objective
This study analysis the spatial and temporal variations of different tumor types of lung cancer incidence rate in Taiwan from 1981-2005, and to explore the relation between soil heavy metals concentration and different tumor types of lung cancer incidence for both gender.
Material and methods
Data on cancer registry system from 1981-2005 and two periods (1982-1986 and 1992-1999) of soil heavy metal concentrations survey data, included soil Arsenic, Cadmium, Chromium, Copper, Lead, Mercury, Nickel, Zinc concentrations was collected from DOH and EAP respectively. To estimate the period effects of different tumor types of lung cancer incidence by APC-Model. Poisson regression model was used to develop relative risks (RRs) of lung adenocarcinoma (lung AC) and lung squamous-cell carcinoma (lung SCC) from 2001-2005 when exposure to different soil heavy metals levels from 1982-1986. In order to prevent the misclassification of exposure, the exposure groups divide into [low-low], [median-median], [high-high] levels according to two periods of soil heavy metals concentrations, and estimate the RRs from 2001-2005 and trends of age standardized incidence rate of lung cancer from 1986-2005 for these exposure groups.
Results
Both male and female, lung AC and lung SCC trends are rising from 1981-2005. The period effect of male lung AC log(RR) increased from -0.78 (1981-1985) to 0.93 (2001-2005), female lung AC log(RR) increased from -1.17 to 1.21, male lung SCC log(RR) increased from -0.59 to 0.55, female lung SCC log(RR) increased from -0.38 to 0.22. Lung cancer RRs of exposure levels by quartile township soil heavy metals concentrations show that soil Copper was related with both male and female lung AC (P value for trend was significant), soil Chromium, Nickel and Zinc was related with both male and female lung SCC (P value for trend was significant). When exposure levels was [high-high] level of two periods soil heavy metals concentrations compares with [low-low] level, there are highest male lung SCC RRs for [high-high] level of soil Chromium (RR=1.59, 95%C.I.=1.37-1.83) and Nickel (RR=1.33, 95%C.I.=1.17-1.83) respectively (P values for trend were also significant for soil Chromium and Nickel). But male lung AC and female lung AC and lung SCC didn’t find any association with soil heavy metals.
Conclusion
This study finds that period effect of lung AC and lung SCC are increased for both male and female from 1981-2005 in Taiwan, and There were spatial variations for lung AC and lung SCC age standardized incidence rate. Township soil Chromium and Nickel concentrations were association with Township male lung SCC incidence.
|
|---|
