The Antimelanogensis and Antioxidation Activities of Traditional Chinese Herbal Medicines

• Main Authors: Ya-Chin Cheng, 鄭雅今
• Other Authors: Hsiou-Yu Ding
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/smj4ht

碩士 === 嘉南藥理科技大學 === 化妝品科技研究所 === 99 === The melanogenesis and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activities of Chinese Herbal Medicines were studied in vitro. We examined 20 traditional Chinese herbal medicines that might be useful for skin-whitening and skin health. Extracts (100 μg/mL) were tested for cytotoxicity on human B-16 melanoma cell; 14 exhibited low cytotoxicity. Their effects on melanin inhibitory activities and free radical scavenging activities were further assessed. Scrophularia ningpoensis and Celosia argentea exhibited potent inhibitory effects on melanin (IC50 values 118.5 and 124.8 μg/mL). The MeOH layer of C. argentea showen with IC50 values 61.6 μg/mL higher activities than α-arbutin (IC50 136.0 μg/mL). Sanguisorba officinalis, Pyrrosia lingua, and Dioscorea nipponica (IC50: 4.9, 4.9, and 6.2 μg/mL, DPPH) showed good antioxidative activities and S. officinalis EA, 95% MeOH layer, BuOH, and H2O (IC50: 4.4, 3.4, 5.7 and 5.4 μg/mL, DPPH) and D. nipponica EA, 95% MeOH layer, and H2O (IC50: 5.2, 3.5, and 4.2 μg/mL, DPPH) showed good antioxidative activities than ascorbic acid.