The Study of microemulsion preparation of C12-15 alkyl benzoate

• Main Authors: Chia-Li Huang, 黃佳莉
• Other Authors: none
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/07046845565100636874

碩士 === 嘉南藥理科技大學 === 化妝品科技研究所 === 99 === Preparation of microemulsion has attracted much attention in cosmetic field due to its thermodynamically stability. The content of emulsifier in microemulsion formulation is typically around 5 to 40%. Skin may lose its protection and barrier function because of the high concentration of surfactant in the formulation and that might induce irritation. In this study, it is attempted to reduce the amount of surfactant used in micro emulsion formulation. The influence of mechanical force, the amount of surfactant and co-surfactant on the formation of microemulsion and the stability of formed microemulsion were studied. The experimental results show that using Tween 20 as surfactant is easier to form microemulsion with C12-15 Alkyl benzoate than using Tween 80. The addition of sorbitol as co-surfactant can reduce the amount of surfactant used for the formation of microemulsion. Different mechanical force has no significant effect on the formation of microemulsion. Due to the high viscosity of the emulsion it is hard to measure the particle size of the emulsion by Dynamic Light Scattering Method. The stability test results shows that a clear solution may become phase separated after three months observation.The results were expressed by ternary-phase diagram. It is concluded that Tween 20 is a better surfactant than Tween 80 for making microemulsion of C12-15 Alkyl benzoate. The addition of sorbitol can significant reduce the amount of Tween 20 used for preparing microemulsion. Clear appearance or particle size alone cannot be the criteria for determining whether the emulsion is microemulisified or not. With the help of ternary-phase diagram it is more clear to see the status of emulsion with varions ratio of oil, water and surfactant phase.