The association between air pollutant exposure and cerebrovascular disease among diabetics in Taiwan

• Main Authors: Shih-Chun Pan, 潘士群
• Other Authors: Wen-Chao Ho
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/55191425729695163317

碩士 === 中國醫藥大學 === 公共衛生學系碩士班 === 99 === The impact of air pollution on health in recent years has been an important public health issue. There has been increasing epidemiological evidence to show that fine particle (PM2.5) could be association with mortality and morbidity of cerebrovascular diseases. Because of the change of life style, diabetes prevalence has been increased year by year in Taiwan. Previous epidemiological studies showed diabetes was also significantly associated with cerebrovascular disease. Our study examined whether diabetes modified the effect of PM2.5 on cerebrovascular disease hospitalization. We used time-stratified case-crossover study design and conditional logistic regression adjusted by temperature and relative humidity to investigate the relationship between air pollutant exposure and cerebrovascular disease hospital admissions in diabetes and non-diabetes groups. The result showed that for each interquartile range increase exposure to PM2.5, the odds ratio (OR) of cerebrovascular disease hospitalization was 1.13 (95%CI= 1.10-1.27) in the diabetes group, but 0.92 (95%CI= 0.84-1.01) in the non-diabetes group. The OR was even higher in diabetic females, 1.26 (95%CI= 1.06-1.49). In a two-pollutant model, the odds ratio after adjusted by SO2 was 1.18 (95%CI= 1.04-1.34) in diabetes and 0.91 (95%CI= 0.81-1.03) in non-diabetes. Similar result was also found in the two-pollutant model with gender specific analysis, that the OR was higher in diabetic females, 1.34 (95%CI= 1.11-1.63). We conclude that persons with diabetes are a susceptible population to air pollution. Diabetes may further modify the effect of fine particle exposure on cerebrovascular disease mobility.