| Summary: | 碩士 === 中國醫藥大學 === 公共衛生學系碩士班 === 99 === Background:
Laryngopharyngeal reflux (LPR) is the result of retrograde flow of gastric contents to the laryngopharynx, which causes chronic or intermittent laryngopharyngeal symptoms. Currently there are few Chinese version quality of life questionnaires for suspected LPR patients.
Aim:
To establish the reliability, validity, and responsiveness of a disease-specific assessment tool, the GERDyzer (Chinese version), which assesses patient-reported outcomes (PRO) with regard to health-related quality of life (HRQoL) of suspected LPR patients.
Methods:
This study was conducted as a single-center multidisciplinary open label, therapeutic trial involving the Voice & Laryngeal Pathology Laboratory and Gastrointestinal Physiology & Motility Laboratory in Taichung Veterans General Hospital, Taiwan. Subjects completed three questionnaires: GERDyzer, RSI and HADs. The outcome assessment was performed at baseline (visit 1), week 4 (visit 2), week 8 (visit 3), and week 12 (visit 4) during the PPI treatment period.
Results:
Validation of GERDyzer indicated high internal consistency (Cronbach’s a = 0.94) and test–retest reliability (intraclass correlation coefficient =0.774). Responsiveness of the total score expressed by nonparametric effect size was 1.14. The correlations showed strong relationships of GERDyzer total scores with RSI score and anxiety score.
Conclusion:
In this study, the GERDyzer (Chinese version) questionnaire displayed good reliability, validity, and responsiveness, so it may provide physicians and patients with a better understanding of the HRQoL burden of suspected LPR and the impact of therapy. The study’s findings demonstrated that the Chinese version of the GERDyzer questionnaire was useful for suspected LPR patients and may be of value in clinical practice.
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