Is Transurethral Resection of Prostate (TURP) Lowering the Risk of Prostatic Cancer for Patients with Benign Prostatic Hyperplasia：A Retrospective Cohort Study

• Main Authors: Hsia-Lang Hsieh, 謝峽浪
• Other Authors: 林文德
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/17316091785292157033

碩士 === 長榮大學 === 醫務管理學系(所) === 99 === Purpose: The main purpose of this study is to prove the hypothesis that transurethral resection of prostate (TURP) procedure, as compared to medications alone, can lower the risk of prostatic cancer for patients with benign prostatic hyperplasia (BPH). Methods: We used the National Health Insurance Database’s one million random sample (LHID 2005) from 1997-2009 as our data source. With a retrospective longitudinal cohort study design, we identified the patients with BPH if they had ICD-9-CM (international classification of disease, 9th version, clinical modification) code of 600.xx, and then followed them up until Dec. 31, 2009 to determine if they had prostatic cancer. According to the aforementioned three groups as control group one another were settled. To achieve the statistical nature of objectivity and impartiality, the use of greedy matching between groups to rationalize the distribution of samples, using survival analysis statistical methods for tracking different outcomes during the periods after their initial therapy. SAS software were used for analysing the large scale samples of database. The P- value with its related confidence interval were used for detecting the credibility of the final results. Results: The hazard ratio (HR) of developing prostatic cancer for BPH patients undergone TURP alone is 0.443 (95%CI: 0.285-0.690,P<.01) compared to BPH patients received medication alone; After PS matching, the HR slightly increase to 0.446 (95%CI: 0.287-0.695, p<.01). For BPH patients undergone TURP combined with medication, the HR is 0.544 (95%CI: 0.358-0.826,P<.05); After PS matching, the HR slightly increase to 0.548 (95%CI: 0.361-0.832, p<.05). Conclusion: Patients with BPH received operative procedure for treatment will decrease the risks of developing prostatic cancer in their future life.