Data integration and mining of influenza virus epitopes.

• Main Authors: Hsuan Fan Jung, 戎炫帆
• Other Authors: G. W. Chen
• Format: Others
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/28174084700370195156

碩士 === 長庚大學 === 資訊工程學系 === 99 === Influenza A virus genome is known to encode 11 functional proteins, in which hemagglutinin (HA) is responsible for the surface antigenicity of the virus and is characteristic for acquiring mutations easily. As a result, structural alteration of hemagglutinin often occurs and causes host immune system fail to detect the virus when it invades host cells. An epitope is a short peptide or single amino acid residue that is associated with antibody recognition. The purpose of this research is to establish an integrated database system of the influenza virus epitopes. We gather the epitope sequences that have been verified by biological experiments upon some fairly limited HA sequences and mark them on hemagglutinin sequences of other thousands of HA sequences in influenza genome database which have yet been investigated by biological experiments. We also establish web interfaces to facilitate the data searching and mining. Biomedical researchers can benefit from using our database in their immune-related researches on influenza viruses.