The High Susceptibility to HCV and Mycoplasma Pneumoniae in Patients of Kidney Dialysis

• Main Authors: Ju-Hsuan Wang, 王如瑄
• Other Authors: Chien-Min Kung
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/w7t249

碩士 === 元培科技大學 === 醫學檢驗生物技術研究所 === 98 === According to United States Renal Data System (USRDS), Taiwan’s prevalence of artificial kidney dialysis (dialysis) ranked first in the incidence rate in 2006. It is still unclear whether or not dialysis patients have a high receptivity towards hepatitis C virus (HCV) and mycoplasma pneumoniae (Mp). Therefore, this study has collected 227 specimens from a certain regional hospital in Taiwan (including 109 blood samples from dialysis patients and 118 blood samples from non-dialysis patients) to conduct HCV and Mp antibody tests and their related blood biochemical items, respectively with the serum samples. Among the tests were total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), GOT, GPT, total bilirubin (T-Bili), direct bilirubin (D-Bili), alkaline phosphatase (Alk-P), and r-glutamyl transferase (r-GT). The results showed that there was a significant increase in dialysis and non-dialysis groups being affected by HCV and the risk was high (38.53% dialysis vs 9.32% non-dialysis; ORs, 6.098; 95% Cl, 2.936-12.662, P <0.0001), and the HCV infected group was found to have a high infection rate and high risk towards Mp (39.62％dialysis vs 18.39% non-dialysis, ORs, 2.912 ; 95％CI,1.489-5.696, P <0.0001). Besides, there was a significant increase in TC (168.28±3.68 vs 191.52±3.41 mg/dl, P <0.0001),HDL-C (37.72±1.35 vs 49.53±1.18 mg/dl, P <0.0001) and LDL-C (168.28±3.68 vs 191.52±3.41 mg/dl, P <0.0001) on dialysis and non-dialysis patients; but there was a significant decrease in TG (183.94±11.50 vs 129.07±7.49 mg/dl, P <0.001) and ALK-P (88.38±4.94 vs 59.47±1.84 U/L, P <0.001).Dialysis patients can indeed be infected by HCV and Mp more easily than non-dialysis patents, and likely to cause significant changes in blood biochemistry. The variances in results among dialysis group can serve as a basis for further research, track counseling or medical healthcare improvement measures in the future.