| Summary: | 碩士 === 國立陽明大學 === 生醫光電工程研究所 === 98 === There are two parts in my experiment. First part, validation experiment including (1) scattering coefficient (2) using DRS to obtain total hemoglobin and oxygen saturation from blood phantom. Second part, preliminary in vivo experiment including (1) the optical and physiological properties of inner forearm (2) the optical and physiological properties of thigh, knee, and leg.
In scattering coefficient experiment, I dilute 10% Liposyn into 4 kinds of concentration : 0.5%, 1%, 1.5%, and 2% then measure the scattering coefficient by DRS. We can get scattering coefficient 5, 10, 15, and 20 (cm-1) respectively.
In blood phantom experiment, I add red blood cell into 1% diluted Liposyn step by step. Then measure the raise of total hemoglobin concentration. Next step, I add yeast into the phantom to consume the oxygen, and take the variation of oxygen saturation simultaneously by DRS.
There are three situations in Inner forearm experiment, (1) rest (2) arterial occlusion to 160mmHg for five minutes (3) occlusion release. We can obtain the variation of optical and physiological properties immediately by DRS.
Last part, we hope we can monitor optical and physiological properties of human tissue in long term. So I take my leg as sample. In many times measurement, the results are stable. According to these results, we can go next step: clinical experiment.
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