| Summary: | 碩士 === 大同大學 === 材料工程學系(所) === 98 === The stainless steel is one kinds of an inorganic material, it`s difficult to immobile the polymer due to its metallic properties. In this study, using plasma treatment to deposit an interface layer, then using UV-induced polymerization to form poly(acrylic acid) hydrogel. It could be used in drug delivery system which is one kinds of pH sensitive hydrogel, and it could be deposited a layer of HMDSZ film to stem drug released. Then immerse into EDC/NHS solution to immobile chitosan and alginate on the surface which suitable for cell adhesion.
The surface wettability will become hydrophile after UV-induced polymerization.It is contributive of chitosan immobilization. Then the amount of chitosan by using acrylic acid immobilization is about 2.08mg/cm2, it is much higher than which is only by surface activation production about 0.24mg/cm2. Besides, the effect of amount of chitosan/alginate mixed solution was followed by alginate ratio increase. As the result of increasing the alginate ratio will favorable for surface immobilization.
The results indicate that plasma deposited HMDSZ film can suspend swelling ratio of poly(acrylic acid) from 43~47 to 25~30 ratio, but in the drug release system is not significantly.
|
|---|
