Establishment of Controlled Release Mechanism for Antibiotic on Titanium Surface by Dip-coating

• Main Authors: Yi-Hao Wu, 吳益豪
• Other Authors: 方旭偉
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/q8hhrn

碩士 === 國立臺北科技大學 === 生物科技研究所 === 98 === Aging population society is the trend of the future. Hence there are more and more elders, who are in urgent need of metal implant, for example, the artificial joint. The artificial joint replacement is one kind of invasive operation, so the risk of the bacterial infection is so high after surgery. Although nowadays’ methods are that patients take a medicine by oral, apply the medical cream or treat a intravenous antibiotiotic therapy after the surgery, there are still some poor treatments and side-effects, and the once more operation is required if the antibacterial result is ineffective. So this study was to apply dip-coating that coat titania nanotubues with gentamicin-contained poly vinyl alcohol (PVA) film, and established the combination model what is to make the gentamicin-loaded poly lactic acid (PLA) microspheres cling on the PVA film surface to achieve two phases drug release and then get the efficacious, long-term antibacterial effect. Experimental results showed that the PVA films made by 15wt％ PVA solution could get the longer drug release effect, in addition, in this PVA concentration the thickest PVA film could made with the 1.6 mm/s start-up speed, and when using the higher drug concentration solution to forming the films, the higher primary drug concentration was released. By reason of the slower degradation time of gentamicin-loaded PLA, the drug was slower released. Finally applying the bacterial inhibition zone test to know the antibacterial effects of the drug-contained PVA films, the drug-loaded PLA microspheres and the combination model. Therefore, by adjusting the concentration of polymer solution, the amount of the drug and the start-up speed to satisfy the efficacious, long-term antibacterial effect in the body in the future.