| Summary: | 碩士 === 國立臺北科技大學 === 化學工程研究所 === 98 === This study aimed to develop deformable Ca-Si-Zn bone restoration complex, and focused on these analyses including mechanical properties, crystalline phases, surface properties, thermal analysis, ionic releasing and in vitro tests. This bone restoration complex is a type of “inorganic-organic” composite. The inorganic composition is Zn0.075Ca2.925SiO5, which was calcined at 1400oC by tricalcium silicate (Ca3SiO5) doped with ZnO. The organic composition is commercial deimmunized collagen. Tricalcium silicate(C3S) is one of the main composition of Portland cement. It provides the property of self-setting, after completely setting, deformation is unable. According to the previous studies, few ZnO doping in C3S could inhibit the formation of free CaO during preparation. ZnO not only stabilizes the structure of C3S but also provides antibiotic ability. In addition, collagen could increase plasticity of the composites and absorb tissue fluid and blood during wound healing.
Zn0.075Ca2.925SiO5 was prepared through a solid-state reaction and then mixed with collagen and NaH2PO4‧2H2O solution as buffer to obtain the complex. This bone restoration complex had a long working time, high plasticity and high compressive strength. So that, this bone restoration complex are able to be shaped in advance before application and served in tissue engineering as scaffolds.
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