Simultaneous confidence interval for the different of the restricted mean lifetimes with right-censored data

• Main Authors: Qi Chang Huang, 黃啟彰
• Other Authors: Yu Mei Chang
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/23481274213398748443

碩士 === 東海大學 === 統計學系 === 98 === In clinical trials and drug development studies, we are often interested in identifying which treatment or does level is more effective than the control or zero dose group in prolonging the survival time of patients. In this thesis, we are finding simultaneous confidence interval on the differences of the restricted mean lifetimes between each treatment and control groups for right-censored survival data. We further conduct a simulation study to investigate the simultaneous confidence interval of the competing procedures under different hazard alternatives, restricted time points and samples sizes. Finally, the use of those procedures is illustrated with two right-censored survival data sets.