Galectin-1 expression can independently predict patient's survival in nasopharyngeal carcinoma

• Main Authors: Shih-Lun Chang, 張世倫
• Other Authors: Tin-Fung Wu
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/39027972083602788534

碩士 === 南台科技大學 === 生物科技系 === 98 === Purpose: Despite the similarities in the pathologic tissues and stages, nasopharyngeal carcinoma has different results and prognoses of radiation therapy or chemotherapy To meliorate the prognoses, more precise prognostic factors, essentially required, modified TNM staging better and detailedly evaluated therapy policy for examining the adjustment necessity. Thence, more active therapies could be provided for poorer prognosis in the nasopharyngeal carcinoma patients, besides the mentioned treatments. Investigating galectin-1 expression in nasopharyngeal carcinoma survival was to more precisely predict the prognoses. Materials & Methods: The 117 nasopharyngeal carcinoma patients were inscribed From 2000 to 2006. In the formalin-fixed paraffin-embedded (FFPE) specimens, the correlation between Galectin-1 expression (in the nucleus and cytoplasm) and disease specific survival was immunohistochemistry-analyzed. Results: Galectin-1 low expression (p=.0041) in the nucleus and Galectin-1 over-expression (p=.0402) in the cytoplasm predicted poorer survival; Galectin-1 over-expression(p=.0467) in the nucleus, poorer metastasis free survival. In Cox regression in nasopharyngeal carcinoma, Galectin-1 low-expression in the nucleus independently predicted disease specific survival (p=.0060); Galectin-1 over-expression in the cytoplasm, metastasis free survival (p=.0384) independently. Conclusion: Galectin-1 expression in the nucleus and cytoplasm was disease specific survival and metastasis free survival correlated in nasopharyngeal carcinoma and can be a crucial prognostic factor for nasopharyngeal carcinoma.