Preparation of Liposomes Encapsulated Ganoderma Lucidum Extract

• Main Authors: Sheng-Tsung Hsu, 許聖宗
• Other Authors: Chang-Chin Kwan
• Format: Others
• Language: en_US
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/50432345433014117325

碩士 === 靜宜大學 === 應用化學研究所 === 98 === Liposomes are spheres made of lipid bilayers, enclosing aqueous volumes. The advantage of liposomal delivery is that separates the functions required for drug delivery. During the 1990s, a number of lipsome-based drugs reached the market in the U.S. and Europe and there has been an explosion of new procedures and techniques in the field. Ganoderma lucidum is used as an edible medicinal material in Chinese medicine. In recent years, many scientific researches have shown G. lucidum has a wide variety of functions. The research focuses on combining liposome with G. lucidum by using thin-film method in order to prepare the liposomes encapsulated G. lucidum extract, and to evaluate its physical stability concerning the particle size and encapsulation efficiency. Based on this study, we found that the optimal drug/lipid ratio still remains high encapsulation efficiency above 61%, and particle size is less than 15.24 μm after three months storage at 4℃.