Studies on the inhibition of Tyrosinase activities and Melanogenesis of the Flavonols complex inducer

• Main Authors: Chiao-yin Hsieh, 謝喬茵
• Other Authors: Jeng-shiow Lai
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/41149425018160903927

碩士 === 靜宜大學 === 化粧品科學系碩士班 === 98 === Nowadays, they use cosmetics to removed black spot is a part of people’s life. This research use nonaqueous solution of LSBMW facter (the flavonols complex inducer) to dissolve with propylene glycol, glycerol and water on the inhibition of tyrosinase activities and melanogensis. In this study, LSBMW factor has: 1.The tyrosinase activties inhibition rate surpasses 100%.2.The B16F10 melanogensis (includes very high Melanin) is not any explicit desalination effect. Then at pH 4, 5.5, 6.8, 8.3, 10.2 PBS do tyrosinase activities inhibition use the LSBMW factor, Ascorbic acid and derivative. Result is 1. LSBMW factor has over 100% inhibition at pH 6.8 PBS. Because LSBMW factor with tyrosinase became to hydrogen bonding compound. 2. LSBMW factor is not easy to be hydrogen bonding at pH 10.2 PBS and inhibition lower to 52%. 3. The future, the LSBMW factor came to be derivative can more easy absorbing by skin.