Clinical applications of modified simplified intravenous glucose tolerance test (MSIVGTT) and homeostasis model assessment (HOMA) in client-owned healthy obese and lean cats

• Main Authors: Yi Ta Chen, 陳依妲
• Other Authors: Biling su
• Format: Others
• Language: en_US
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/38780148045648167995

碩士 === 國立臺灣大學 === 臨床動物醫學研究所 === 98 === Intravenous glucose tolerance test is a suggested method to evaluate the glucose homeostasis in cats. However, anesthesia and hospitalization required in performing the test hamper its clinical application. In order to establish a clinical applicable test, 34 client-owned cats were enrolled in this study. A modified simplified intravenous glucose tolerance test (MSIVGTT), a simple indice of insulin sensitivity homeostasis model assessment (HOMA) were evaluated for their applicability in the detection of glucose intolerant patients. The modifications include accompany of the pet owner, application of winged infusion set connected with the catheter for repeatable blood sampling, lay of the examined cats upon a soft pet bed and covered with a towel, as well as shorten the examined procedure to 3 hours. All cats were divided into obese and lean groups based on the feline body mass index (FBMI). Complete evaluation was achieved from 32 out of 38 cats (84%) using MSIVGTT and the results showed statistical differences between obese and lean cats with slower glucose disposal rate in glucose response and exaggerated insulin secretion in the 2nd phase of insulin response in the obese cats. Moreover, the test also screens out 3 impaired glucose tolerant cats from the 32 cats. The HOMA showed significant difference between two groups and had a positive correlation with the obese condition of the 38 cats. In conclusion, MSIVGTT and HOMA were established for clinical usage evaluation of glucose homeostasis. Application of these 2 assays can be used to screen out impaired glucose tolerant cats in clinical practice.