Optical Coherence Tomography and Oral Disease Diagnosis Application

• Main Authors: Cheng-Kuang Lee, 李正匡
• Other Authors: 楊志忠
• Format: Others
• Language: en_US
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/66312433252391361229

博士 === 臺灣大學 === 光電工程學研究所 === 98 === Optical Coherence Tomography (OCT) is a noninvasive, high resolution imaging technique for biomedical applications. OCT can provide images with resolution 1-15 microns in the longitudinal direction. OCT has been widely used in biomedical imaging, particularly in ophthalmology. In oral cancer study, the capability of OCT for imaging the underlying structures of both benign and malignant oral mucosa was also demonstrated. In this dissertation, we first propose two indicators, including epithelium thickness and laminar propria standard deviation, to diagnosis oral submucous fibrosis. Second, we propose a computer analysis procedure of OCT images for real-time oral pre-cancer diagnoses. OCT scanning uses the interfered backscattered coherent signal for retrieving sample structures. Therefore, any contrast agent, which can enhance coherent backscattering, can be used for increasing OCT image quality. We use the Au nanoring as the contrast agent because its localized surface plasmon properties have found broad applications in emission and absorption enhancements. The Au nanorings are delivered into pig adipose samples for OCT scanning to demonstrate the enhanced absorption and scattering behaviors of LSP resonance. And then, we track the resonant Au NR diffusion in a mouse liver tissue with OCT scanning.