A network-based biomarker approach for molecular investigation and diagnosis of lung cancer
博士 === 國立清華大學 === 電機工程學系 === 98 === 癌症是一種細胞不正常的增生而造成腫瘤的一種複雜的疾病,而肺癌又是眾多癌症中致死率最高、全世界造成死亡數最多的一種癌症。有許多的論文致力於研究致癌的過程以及尋找可以分類特徵的生物標記,這樣的癌症生物標記通常被用來當作診斷評估的工具或是預後情況的指標。然而,就我們所知,目前並沒有令人滿意的以網路為基礎的方法,從系統的觀點來研究致癌的機制及診斷。因此,在這篇論文中,我們提出了一個結合微陣列基因表現以及蛋白質交互作用資訊的系統生物學方法,用來發展生物網路標記以進行肺癌分子研究及診斷。我們利用這樣的資料,結合一個簡單的線性迴歸模型以...
Main Authors: | Wang, Yu-Chao, 王禹超 |
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Other Authors: | Chen, Bor-Sen |
Format: | Others |
Language: | en_US |
Published: |
2010
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Online Access: | http://ndltd.ncl.edu.tw/handle/32614531718953834930 |
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