ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis

ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis

碩士 === 國立中山大學 === 生物科學系研究所 === 98 === ROGDI was a novel gene with unknown function, located on human chromosome 16p13.3. The coding region of the gene is 864 bp that encodes 287 amino acids. According to GenBank database, ROGDI contains leucine zipper domain. Previous studies in our laboratory s...

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Main Authors: Hong-meng Chuang, 莊弘盟
Other Authors: Chung-Lung Cho
Format: Others
Language:zh-TW
Published: 2010
Online Access:http://ndltd.ncl.edu.tw/handle/80286867116605390167
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spelling ndltd-TW-098NSYS51121232015-10-13T18:39:47Z http://ndltd.ncl.edu.tw/handle/80286867116605390167 ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis ROGDI活化p53引發肝癌細胞株對抗癌藥物的敏感化與凋亡 Hong-meng Chuang 莊弘盟 碩士 國立中山大學 生物科學系研究所 98 ROGDI was a novel gene with unknown function, located on human chromosome 16p13.3. The coding region of the gene is 864 bp that encodes 287 amino acids. According to GenBank database, ROGDI contains leucine zipper domain. Previous studies in our laboratory showed that ROGDI increases cell proliferation in cell lines. In addition, overexpression of ROGDI induces p53 and p27 mRNA levels in human glioma cell line T98G and U251. In this study, we use two hepatocellular carcinoma cell lines, Hep G2 and Hep 3B, which contains wild-type and deleted tumor suppressor protein p53 respectively to investigate the expression of p53 and the response of anticancer drugs treatment in ROGDI overexpression cells. In addition, we compare the relation between the cell apoptosis the expression of p53 and ROGDI. Hence, we found that expression of p53 and ROGDI influences the cell response to anticancer drugs and induces apoptosis. Chung-Lung Cho 卓忠隆 2010 學位論文 ; thesis 77 zh-TW
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language zh-TW
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description 碩士 === 國立中山大學 === 生物科學系研究所 === 98 === ROGDI was a novel gene with unknown function, located on human chromosome 16p13.3. The coding region of the gene is 864 bp that encodes 287 amino acids. According to GenBank database, ROGDI contains leucine zipper domain. Previous studies in our laboratory showed that ROGDI increases cell proliferation in cell lines. In addition, overexpression of ROGDI induces p53 and p27 mRNA levels in human glioma cell line T98G and U251. In this study, we use two hepatocellular carcinoma cell lines, Hep G2 and Hep 3B, which contains wild-type and deleted tumor suppressor protein p53 respectively to investigate the expression of p53 and the response of anticancer drugs treatment in ROGDI overexpression cells. In addition, we compare the relation between the cell apoptosis the expression of p53 and ROGDI. Hence, we found that expression of p53 and ROGDI influences the cell response to anticancer drugs and induces apoptosis.
author2 Chung-Lung Cho
author_facet Chung-Lung Cho
Hong-meng Chuang
莊弘盟
author Hong-meng Chuang
莊弘盟
spellingShingle Hong-meng Chuang
莊弘盟
ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis
author_sort Hong-meng Chuang
title ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis
title_short ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis
title_full ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis
title_fullStr ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis
title_full_unstemmed ROGDI activates p53 and leads to sensitization for anticancer drug-induced apoptosis
title_sort rogdi activates p53 and leads to sensitization for anticancer drug-induced apoptosis
publishDate 2010
url http://ndltd.ncl.edu.tw/handle/80286867116605390167
work_keys_str_mv AT hongmengchuang rogdiactivatesp53andleadstosensitizationforanticancerdruginducedapoptosis
AT zhuānghóngméng rogdiactivatesp53andleadstosensitizationforanticancerdruginducedapoptosis
AT hongmengchuang rogdihuóhuàp53yǐnfāgānáixìbāozhūduìkàngáiyàowùdemǐngǎnhuàyǔdiāowáng
AT zhuānghóngméng rogdihuóhuàp53yǐnfāgānáixìbāozhūduìkàngáiyàowùdemǐngǎnhuàyǔdiāowáng
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