Effects of Vitamin E and Fructooligosaccharides in Dietary on Bone Effects of Vitamin E and Fructooligosaccharides in Dietary on Bone Properties in Aging

• Main Authors: WANG YI JOU, 王銥葇
• Other Authors: 紀偉民
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/41710345444404850120

碩士 === 南開科技大學 === 福祉科技與服務管理所 === 98 === Dietary supplemented of vitamin E and Fructooligosaccharides in Lasc Balb/c mice induced aging by D-galactose was used to examine the effects of bone mechanical properties. This study took 92 Lasc Balb/c mice, 10-week, as the experimental subjects and divided them into four groups: Group C, natural aging (n=23), was hypodermic injected Saline (0.3 cc/day). Group D, accelerate aging (n=23), was hypodermic injected (Saline (0.3 cc/day)＋10% D-galactose). Group C and D were supplemented ordinarily. Group E was hypodermic injected (Saline (0.3 cc/day)＋10% D-galactose) and was supplemented Vitamin E. Group F was hypodermic injected (Saline (0.3 cc/day)＋10% D-galactose) and was supplemented Fructooligosaccharides. After 50 days’ experimental diets, this study took both of the hind legs. The mechanical properties of a left femur were measured by three-point bending test. Right femur was measured of weight, volume, bone mineral density (BMD) and porosity rate. The result showed that group C and D had significant difference on the stiffness and the toughness. The mechanical property of femur obviously became more brittle, easily broken after injecting the D-galactose. Simultaneously, groups supplemented vitamin E or Fructooligosaccharides, as far as mechanical properties of femur concerns, such as: stiffness, strength and toughness and ultimate strength, there was no significant effect. In comparison of the four groups the right femur’s pore volume and porosity also had no obvious difference. Probably because of the femur itself was too small to measure the volume of water and might affect the accuracy of measurements. Conclusion: The dietary supplement of vitamin E and Fructooligosaccharides are not significantly to increase the intensity of animal bones and prevent the occurrence of aging.