To study the potential modulation effect of cellular microRNA on flavivirus infection

• Main Authors: Wei-Tzu Chiu, 邱唯慈
• Other Authors: Yi-Ling Lin
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/75479753331429099807

碩士 === 國防醫學院 === 微生物及免疫學研究所 === 98 === MicroRNAs (miRNAs) are small noncoding RNAs of approximately 21~23 nucleotides in length. They are derived from cellular or viral transcripts and bind to their target mRNAs in a sequence-specific manner, resulting in either mRNA degradation or translational repression. Recent studies suggest that cellular miRNAs are among the key determinants controlling virus infection in mammalian hosts, for example cellular miRNAs can serve as restriction factors to limit infection by several viruses, including human immunodeficiency virus and vesicular stomatitis virus. However, our understanding on the role played by cellular miRNA on flaviviruses is limited.