Synthesis and bio-analysis of hydantoin series compounds as potential anticancer agents

• Main Authors: Tsai, Meng-Jeng, 蔡孟錚
• Other Authors: Chang, Tsu-Chung
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/23484894082431174932

碩士 === 國防醫學院 === 生物化學研究所 === 99 === Hydantoin scaffold possess a wide diversity of biochemical effects and pharmacological properties. So it is of interest to design and synthesize new hydantoin derivatives, and discover new potent antitumoral agent, with anti-growth, anti-migration, anti-invasive properties against HeLa and PC-3 cells. In addition, compounds which strengthen cell-cell adhesion can potentially server as anti-metastasis agent. Our results suggested compounds bearing the alkyl group substituent at N-3 position of hydantoin, will not improve antitumor activities. On the other hand, compounds with double bond at C-3 position substituent, show significant improve in antitumor activities. Thus, C-3 position of hydantoin plays an important role in determining antitumor activities against HeLa and PC-3 cells. Our results also suggested compound C and E are the best antitumor agent.