Effect of Inulin Supplementation on Metabolic Syndrome Risk Factors, Antioxidant and Inflammatory Markers

• Main Authors: Tun-Ping Wu, 吳惇平
• Other Authors: Shu-Mei Lin
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/35389874082494519393

碩士 === 國立嘉義大學 === 食品科學暨生物藥學研究所 === 98 === ABSTRACT Metabolic syndrome refers to a group of obesity-related factors that are associated with increase risk of cardiovascular disease, diabetes, and some types of cancer and chronic diseases. According to 2006 Statistic Major Causes of Death, metabolic syndrome is risk factor for five in ten leading causes of death which accounts for 30.4 percent of death in Taiwan. Prevalence of metabolic syndrome is closely correlated with dietary pattern and life style. High fiber diet has been reported to provide beneficial effect in preventing metabolic syndrome primary by reducing blood cholesterol and postprandial glucose levels. Inulin is a class of polysaccharide composed of fructose units linked by β (2→1) glycosidic bond that resists to hydrolysis by intestinal digestive enzymes, and is classified as a water soluble dietary fiber. The aim of this study is to determine whether including inulin in the diet improved metabolic syndrome and cardiovascular diseases risk in adults with abdominal obese. Twenty-five adults with waist circumference higher than normal range and one of other criteria for metabolic syndrome were recruited to participate. The participants received 25 g inulin every day for 8 weeks without additional dietary and life style modification. Anthropometric measurement, dietary analysis, blood biochemical examination including lipid profile, inflammatory index and antioxidant capacity were performed before and after the 8-week supplementation. The results showed that body weight, body mass index (BMI), and diastolic blood pressure did not change, whereas percentage body fat, waist circumference and systolic blood pressure significantly decreased (p < 0.001) after inulin supplementation, and the magnitude of the decrease was greater in female than in males participants. Blood glycosylated hemoglobin (HbA1c) level was significantly lower (p < 0.001) compared with baseline, while there was no difference in fasting glucose level, blood lipid profile and serum inflammatory index including interleukin-1(IL-1), interleukin-6 (IL-6) and tumor necrosis factor (TNF) and high sensitivity C-reactive protein (hs-CRP). Antioxidant analysis indicated that malondialdehyde (MDA)concentration and catalase activity (p = 0.006) decreased, and glutathione (GSH) content (p = 0.008) increased with the supplementation. There was no significant effect on erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. In conclusion, inulin supplementation may provide health-promoting effect by modulating body composition, blood pressure and redox status, and is a potential strategy for long-term blood glucose management and cardiovascular protection.