| Summary: | 博士 === 國立中央大學 === 電機工程研究所 === 98 === As the potential threat of an aging society increases, there is great need for a tool that can quickly, conveniently, and accurately detect the symptom of any disease at the self-care stage. Biosensors can essentially serve as a low-cost and highly efficient device for this purpose in addition to other day-to-day applications. This study discusses advances in impedimetric and piezoelectric sensor technology, which draw on the disciplines of materials, chemistry, and electronics. This study shows that a biosensor with a difference transducer consists of three components, a reorganization layer, a transducer, and an output circuit system. According to different detection targets, the reorganization layer of this study follows common immobilization procedures for efficacious attachment on the transducer surface. Based on different immobilization procedures, this study successfully uses the impedance sensor applied in DNA, protein, and animal cells. Then, a “specific reorganization layer” recognizes a specific analyte to show that the electrical signal utilizes a converted impedance sensor. The other part of the study develops a lead zironate titanate (PZT) chip as a novel sensitive gravimetric biosensor by reducing size and using the resonance feature in biomolecule detection. Two types of transducers in this article, impedimetric and piezoelectric, provide the microfabrication technique of sensing chip and readout circuit formation. Subsequently this article discusses a few practical factors in several experiments as different case studies affecting biomedical application and commercialization of impedimetric and piezoelectric biosensors.
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