Exact non-inferiority test based on conditional odds ratio for matched-pair data

碩士 === 國立中央大學 === 統計研究所 === 98 === This article considers testing against the noninferiority of a testing treatment to a reference treatment based on the conditional odds ratio for matched-pair data. Approximated confidence bounds for the odds ratio are first derived from existed approximate tests....

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Bibliographic Details
Main Authors: Ting-Huei Li, 李庭慧
Other Authors: Yuh-Ing Chen
Format: Others
Language:zh-TW
Published: 2010
Online Access:http://ndltd.ncl.edu.tw/handle/00452335275057403116
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Summary:碩士 === 國立中央大學 === 統計研究所 === 98 === This article considers testing against the noninferiority of a testing treatment to a reference treatment based on the conditional odds ratio for matched-pair data. Approximated confidence bounds for the odds ratio are first derived from existed approximate tests. However, the minimum coverage probabilities of the approximate confidence bounds lose to maintain their nominal level. Therefore, the approximate confidence bounds are modified based on the results in Buehler (1957), and the exact noninferiority tests are obtained. The type I error rates and power are then computed to evaluate the performance of the approximate and exact noninferiority tests. Finally, the exact tests are illustrated by using a real data set.