Plasma haptoglobin is an acute-phase protein responsive to exercise: A physiologic role and its mechanism involved

• Main Authors: Hsieh, Wan-Ling, 謝宛伶
• Other Authors: Mao, Simon J.T.
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/00902676313881812397

碩士 === 國立交通大學 === 分子醫學與生物工程研究所 === 98 === Haptoglobin (Hp), an anti-inflammatory and antioxidant molecule, is primarily synthesized in lung and liver and sharply increases during inflammation or infection. One of the major functions of Hp is to scavenge the free radicals produced from Fe3+-hemoglobin following the hemolysis of red blood cells. Because after a short-term bout of exhaustive exercise is usually associated oxidative stress, we tested a hypothesis that exercise may elevate plasma Hp in order to reduce the resulting oxidative stress. Mice (n=24) were divided into four groups with 0, 1-, 2 and 3- week passive exercise. First, we demonstrated for the first time that plasma Hp increased substantially overtime following the exercise. Next, we showed neutrophil being significantly increased after three-week exercise (p<0.05). Interestingly, the Hp mRNA of liver, a major organ for Hp synthesis, remained unchanged. Thus, the data indicate that exercise may induce the plasma Hp levels by primarily using neutrophils as a source. Because Hp is an extremely potent antioxidant, the present study suggests that elevated Hp may play a potentially protective role to reduce the oxidative stress during the exercise.