Statistical Analysis for Familial Case-Control Data

• Main Authors: Su, Hsiao-Lan, 蘇筱嵐
• Other Authors: Wang, Wei-Jing
• Format: Others
• Language: en_US
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/69736066139604897765

碩士 === 國立交通大學 === 統計學研究所 === 98 === Familial case-control data are frequently used to study the relationship between disease and risk factors. In the thesis, we review literature for analyzing familial data. The logistic model is applied to model the probability of disease incidence. The Cox proportional hazards model is applied to model the age at onset of the disease. For each model, we discuss how to extend the method and model developed for individual data to familial data. In addition, we discuss the criteria and modification from prospective data to case-control data. We also propose simulation algorithms for generating case-control data and then, based on simulated data, examine parameter estimates and crucial properties of the inference procedure.