A Novel Injectable Colloidal Nanogel with Extremely High Water Content for Drug Delivery

• Main Author: 蕭孟軒
• Other Authors: 劉典謨
• Format: Others
• Language: en_US
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/24694637520203574097

碩士 === 國立交通大學 === 材料科學與工程學系 === 98 === A novel colloidal injectable nanogel was successfully prepared based on an amphiphilically-modified chitosan prepared previously in this lab, which underwent a thermally-induced sol-to-gel transition upon a temperature change from ambient to physiological environment. Amphiphilic nature of the modified chitosan rendered subsequent self-assembly forming nanocapsules in aqueous solutions. Gelation occurred even with less than 1% nanocapsules upon a change in temperature over reasonable time duration, forming a solid-gel entity in situ. A subsequent application to carry drugs of various degree toward water affinity (from water soluble, ethosuximide (ESM), to water insoluble, CPT), following a controlled drug release in vitro has been systematically investigated. The experimental results indicated a long-term, sustained release profile for both types of drugs were monitored and release kinetics suggested a two-stage profile, suggesting a bimodal release pattern, and has been confirmed to be a result of drug distribution, i.e, within the nanocapsules and inter-capsule regions. This finding implies a dual drug release capability can be designed and fulfilled simultaneously using current nanogel system. Biocompatibility, Sol-to-gel transition, nanostructure, and biocompatibility of the nanogel were characterized, and was considered as a novel water-borne drug delivery system.