Gene-Temperament Interactions Might Distinguish between Bipolar I and Bipolar II Disorders: A Cross-Sectional Survey among Han Chinese in Taiwan

• Main Authors: Yi-AnnLu, 呂怡安
• Other Authors: Ru-Band Lu
• Format: Others
• Language: en_US
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/00601577044146234480

碩士 === 國立成功大學 === 行為醫學研究所 === 98 === Background: It has been debated whether bipolar II disorder (BP-II) a distinct disorder or simply a milder form of bipolar I disorder (BP-I). Methods: In this cross-sectional survey (2005-2009), we administered the Hamilton Depression Rating Scale (HDRS), the Young Mania Rating Scale (YMRS), and the Tridimensional Personality Questionnaire (TPQ) to 314 participants (82 BP-I patients, 121 BP-II patients, and 111 healthy controls). The Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3), and the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotypes were examined. All the patients met the DSM-IV-TR diagnosis of bipolar disorder. Results: Multinomial logistic regression analysis showed a significant main effects for the 5-HTTLPR polymorphism (p = 0.045), novelty seeking (NS) (p = 0.033) and harm avoidance (HA) (p = 0.012) scores, and a significant interaction effect between HA and 5-HTTLPR genotypes (p = 0.047) in distinguishing between BP-I and BP-II patients. BP-I patients with the long allele at 5-HTTLPR had lower HA scores than did BP-II patients (BP-I = 16.23, BP-II = 19.80; p = 0.023). Multinomial analysis also showed that NS (p = 0.001) and HA (p = 0.001) scores significantly differed between BP-I patients and healthy controls (HC). However, only HA (p ＜ 0.001) significantly differed between BP-II patients and healthy controls. All these data suggest a distinction between BP-I and BP-II. Conclusions: We provide initial evidence that 5-HTTLPR genotypes moderated the association between HA and BP-I and BP-II. We hypothesize that there are unique differences in the gene-temperament interactions of BP-I and BP-II patients.