| Summary: | 碩士 === 國立成功大學 === 醫學工程研究所碩博士班 === 98 === Avascular necrosis of femoral head (AVNFH) is a disease of impaired osseous blood flow. It commonly affects patients from the third to fifth decade of life and is dominant in male patients. In Taiwan, due to factors such as corticosteroid and alcohol abuse, its incidence was increasing year by year. Avascular necrosis of femoral head will eventually come to total hip replacement surgery in end stage, that is a tremendous impact of individual’s lifestyle, economy and social costs. In spite of vascular factor, the biomechanical factor is another influent factor on AVNFH. In this study, finite element analysis is used to simulate the process of avascular necrosis of femoral head and investigate the direction and process of the evolution of the necrotic region. The results are compared with clinical magnetic resonance imaging to verify its legitimacy.
In the research, the superiolateral femoral head is assumed to be the initiation of avascular necrotic region. Single leg standing condition was applied as loading. Simulation of the process of necrosis is from the sponge bone layer which spread internally, eventually render the crescent shell. This is coincided with crescent sign in clinical patient’s X-ray of mid-stage avascular necrosis of femoral head. The Study shows that the possible mechanism of proliferation of necrotic region is the local bone tissue to withstand the abnormally high stress. The vascular factors play an initiation factor, but biomechanics play an important role in subsequent necrosis and eventual collapse. Relevant information will help in the conservative treatment policy and planning decompression or reinforced surgery. It provides information and establishes a foundation for further study.
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