Fabrication of Biodegradable Silica Nanotubes and Their Applications in Drug Delivery and MRI

• Main Authors: Kang-CheHsu, 許綱哲
• Other Authors: Chen-Sheng Yeh
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/82574097752450423372

碩士 === 國立成功大學 === 化學系碩博士班 === 98 === In the past few decades, nanoscale materials have shown promise for drug delivery platform. Considerable studies have shown that many non-degradable inorganic nanomaterials are harmless to cultured cells or in animal models, either in nature or functionalized. However, the development of biodegradable nanomaterials, which can be excreted from the human body, is still strongly anticipated by medical practitioners. In this study, a pH-dependence of degradable silica nanotube is fabricated, which is dissolved to bodegradation product silicic acid in water. The silica nanotube is resistant to acidic condition, but degrades rapidly at pH 8. And the degradation rate can be tuned via tailoring the shell thickness of silica nanotube, which is dissolved more slowly with thicker shell. This feature of degradation makes silica nanotube act as a potential oral-based administration carrier. Because silica-based materials are readily functionalized via surface modification, silica nanotube can be further developed as MR imaging contrast agent as well as drug carrier. The realeased Gd3+ ions resulting from the etching of Gd(OH)3 nanorod are chelated by chelating agent DOTA, which is pre-modified on silica nanotube, yielding DOTA-Gd grafted silica nanotube. Finally, the DOTA-Gd grafted silica nanotube which is loaded with anticancer drugs, show enhanced T1 relaxation and anticancer activity simultaneously.