1. Synthesis of CuO on mesoporous silica and its applications for coupling reactions of C-S bond2. A simple copper-catalyzed thioetherification of aryl iodides with thiols

• Main Authors: Chih-Keng Chen, 陳志耕
• Other Authors: Chin-Fa Lee
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/11556051788206607374

碩士 === 國立中興大學 === 化學系所 === 98 === Aryl thioethers are important compounds in pharmaceutical and biological chemistry. Transition-metal-catalyzed cross-coupling reaction is a powerful method for constructing C-S bond. 　　The first part of this thesis is to develop a new type of catalyzst-CuO on mesoporous silica, this material exhibits well-dispersed CuO active sites and shows high reactivity towards cross-coupling reactions of thiols with aryl iodides without any additive ligand. The catalyst could be used under 1.0-5.0 mol% loading and could be reused for several times without lossing its activity. 　　In second part, we report that the commercially available Cu2O powder can be applied as a very reactive catalyst for the coupling reaction of thiols with aryl iodides under ligand-free conditions. A variety of functional groups such as free-alcohols, unprotected amines, esters, and heterocycles were tolerated by the reaction conditions explored.