| Summary: | 碩士 === 明新科技大學 === 光電科技產業研發碩士專班 === 98 === The surface plasmon resonance (SPR) detection system is a powerful sensor for
surface bio-molecules, which is generally used in biological, chemical, and medical
researches. In the surface plasmon resonance detection system, a linear polarized light
beam is coupled by a prism and then incident into one 50nm thick metal thin film.
When the incident angle equals to the surface plasmon resonance angle, the incident
energy will be absorbed by the metal thin film and converted to surface plasmon
resonance. It brings to that the reflectance is greatly declined. The work principle of the
surface plasmon resonance detection system is that the metal film of the sensor attaches
the test samples in the solution to arise a change once the resonance condition is
satisfied. According to the changed parameter of the resonance condition in the
detection, the detection system can be classified as, resonance wavelength, resonance
intensity type systems, etc. Today most surface plasmon resonance detection systems
used in researches are resonance angle type and produced by BIAcore company. The
systems described above all have some common defects. (1) The thickness of the metal
film must be very precise, around 50nm. Therefore, the yield efficiency of surface
plasmon resonance detection chip is not high. Moreover, it is not easy to keep the metal
film in a good condition, and the chip only can be used once resulting in the increase of
cost. (2) They cannot do multi-points detection and the detection amount is less. Also, it
can not be used to detect the interaction between different organisms.
According to the defects described above, we are going to produce a having the
recyclable detection chip which has less influence on metal film in this project. The
design of this multichannel surface plasmon resonance detection systems adopts the
combination (1)Kretschmann configuration attenuated total-reflection coupling system,
and (2) planar substrate optical waveguide to overcome the defects of the defects of
traditional surface plasmon resonance detection system, and help the industry to build
up low cost multichannel surface plasmon resonance detection systems.
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