Porous bioceramic made by thermo-responsive hydrogel and combined with nanocarriers of drug to evaluate bone healing

• Main Authors: Shih-Ciang Chien, 簡士強
• Other Authors: Chih-Kuang Wang
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/68414218546374734417

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 98 === Tissue engineering has proved to be one of the most promising therapies for bone fracture defects [1]. This new paradigm requires scaffolds that balance temporary mechanical function with mass transport to aid biological delivery and bone repair [1]. It has been reported that of HAp/TCP (hydroxyapatite/tricalcium phosphate) promotes the new bone formation from in vivo experiments [2]. While, porous bioceramic acts as a scaffold for the rapid ingrowths of vascularized connective tissue and bone. According to the current literature the optimal pore size is estimated to be 80~160 [3] or 500~1000 ?慆 [4]. Besides the strength acts the performance of porous hydroxyapatite ceramics. However, the compressive strength of cancellous bone will be ~5 MPa [5]. Several technologies exist today to manufacture strong and reliable porous ceramics. But these scaffolds prepared methods maybe can have a controllable pore size, interconnected pores, and desired geometry but often poor mechanical strength for load-bearing applications [5]. Besides, statins have potent compounds that inhibit cholesterol synthesis in the liver and have been reported to induce bone formation, both in tissue culture and in rats and mice [6, 7]. However, the high concentration of simvastatin have rhabdomyolysis side effect [6]. In this study, we report a novel technique that integrates the thermo-responsive hydrogel technique with porogen polymer method to prepare HAp/TCP porous scaffolds with improved mechanical strength and controllable porous structure. The hypothesis is that thermo-responsive hydrogel will shrink with the temperature increasing; then the function can be regarded as isostatic cold pressing (ICP) effect before ceramic sintering. Meanwhile, we filled appropriate simvastatin in porous bioceramic to obtain optimal release profile.