Survival Analysis of the Prognostic Factors among the Patients with Breast Cancer-A Case Study of Regional Teaching Hospital

• Main Authors: Chih-Hsien Chou, 周芷嫻
• Other Authors: Yong-Yuan Chang
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/54702728166635281236

碩士 === 高雄醫學大學 === 公共衛生學研究所 === 98 === Objective:This study aimed to assess prognostic factors on mortality and recurrent rate of patients diagnosed as breast cancer. Methods and Materials:From January 2000 to December 2007,the study performed a retrospective review of 418 patients with stageⅠ-Ⅲ invasive breast cancers, and followed-up to December 2008.Patients,disease and treatment data were extracted from medical records and pathological records.The Kaplan-Meier mothod and log-rank test were used to estimate and compare the survival and non-recurrent rate.The effects of potential prognostic factors were assessed using Cox proportional hazards model or time-dependent covariates Cox regression model. Results: 418 patients with a median age of 50. 5-year non-recurrent rate was 79% ,and 5-year survivial rate was 87%.Using univariate analysis we found,prognostic factors related to recurrent rate were stage,tumor size, positive axillary lymph node,histological grade,nuclear grade, vascular invasion,and treatment modality; prognostic factors related to survival rate were stage,tumor size,positive axillary lymph nodes, histological grade,nuclear grade, vascular invasion,PR status and treatment modality. The multivariate analysis after controlling the other covariates factors, positive axillary lymph nodes were found significantly impact on recurrent rate.After controlling the other factors, positive axillary lymph nodes,stage, histological grade,PR status, and treatment modality*stage were found significantly impact on mortality. Conclusion: Positive axillary lymph nodes is an independent predictor of recurrent rate after consideration of other strong prognostic factors, except that positive axillary lymph nodes,stage,histological grade, PR status, and treatment modality*stage were independently prognostic factors of mortality.