| Summary: | 碩士 === 弘光科技大學 === 營養醫學研究所 === 98 === Oxygen free radicals cause DNA damage is an important factor affecting the aging process, leading to the root causes of disease and aging. The accumulation of peroxide oxidation of reactive substances will begin to proteins, nucleic acids and lipids, and activation of apoptosis pathway. At the same time, oxidative stress may stimulate cells of cyclooxygenase II (COX-2) promote the expression of nerve cells to die. Thus, oxidative stress by lowering the cell to reduce the rate of aging of nerve cells, will be able to slow the aging effect. Modern pharmacological studies show that Cuscuta has cancer, promote immune function and anti-oxidation effect. Astragalin as herbal extracts of Cuscuta chinensis, Convolvulaceae. structure is, in previous studies have found Convolvulaceae such molecules, such as Epimedium or velvet, are of great benefit yang of the kidney and marrow. In this study, injection of galactose long-term use result in aging organisms peroxidation in vivo model, observed in vivo Astragalin whether the effect of slowing down aging. The results show that Cuscuta chinensis induced aging model will significantly improve the serum biochemical indicators
associated with aging, while Astragalin, you can delay the appearance of aging index. These results suggested that Astragalin may, through its antioxidant capacity to achieve neuroprotective and can control NF-kB to reduce the
expression of COX-2 gene expression, while Astragalin can also delay the galactose induced aging, there fore, to expect to delay the coming into the health of aging and mental health-care products.
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