The effect of 18β-Glycyrrhetinic acid derivative in skin physiology

• Main Authors: Wen-Hao Hsieh, 謝文豪
• Other Authors: Chi-Feng Hung
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/90838647178070014353

碩士 === 輔仁大學 === 基礎醫學研究所碩士班 === 98 === The aquaporins-3 (AQP-3) is a small integral membrane protein (monomers~30 kDa) that facilitates water and small solute(s) such as glycerol transport. There are many studies indicating that enhanced AQP-3 expression facilitates skin wound healing by increasing cell migration and cell proliferation. In our study, we found that the treatment with the derivative of 18β-glycyrrhetinic acid (18beta-GA-d), is the bioactive compound of licorice which has been used in herbal medicine for skin eruptions including eczema, dermatitis, and cysts, induces AQP-3 expression in a dose- and time-dependent manner in skin fibroblasts and HaCaT cell. Furthermore, we found that 18beta-GA-d also facilitates cell proliferation and migration in a time- and dose-dependent manner in human skin fibroblasts and HaCaT cell. 18beta-GA-d also induced the phosphorylation of PI3K and AKT. Our results suggest that the 18beta-GA-d may be a new agent which treats skin or other diseases via the increase of AQP-3 expression.