Effects of particulate and carbon monoxide exposures in different public transits on heart rate variability in healthy young adults

• Main Authors: Tzu-Yi Wu, 吳姿儀
• Other Authors: Chin-Sheng Tang
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/6g5p62

碩士 === 輔仁大學 === 公共衛生學系碩士班 === 98 === Introduction Recent epidemiologic studies have assessed the health effect of air pollution on cardiac autonomic function and cardiovascular function by measuring heart rate variability (HRV). Several studies have found significant impacts of particulate matter (PM) and carbon monoxide (CO) on HRV. In the current study, we evaluated the short-term effects of multi-sized PM and CO exposures in different public transits on HRV changes in healthy young adults. Methods We recruited 20 young healthy adults (10 males and 10 females, aged 18-27 years) from campus dormitory. In addition to electrocardiogram (ECG), personal exposures to PM2.5-10, PM1-2.5, PM1 and CO in campus, bus and mass rapid transit (MRT) were continuously monitored by portable ECG recorder(MSI E3-8010), portable dust monitor(Grimm 1.108), and gas detector (Dräger PAC III). HRV parameters assessed included heart rate (HR), r-MSSD, SDNN, pNN50, LF, HF, TP, and LF/HF ratio. Generalized additive mixed model (GAMM) was applied to estimate the effects of PM and CO concentrations on HRV changes, adjusted for personal and meteorological variables under single- and multi-pollutants models. Results Personal exposures to all sized PM and CO in public transits were significantly higher than those in campus. As compared with HRV measured in campus, the percent changes in r-MSSD, SDNN, pNN50+1, LF, HF, and TP decreased, but the percent changes in HR and LF/HF increased when subjects located in public transits. Adjusting for all locations, 5-min PM2.5-10 and PM1 moving average increased the percent changes in HR and SDNN significantly. Additionally 5-min PM2.5-10 moving average decreased the percent change in HF, but increased the percent change in LF/HF, significantly. The reduction of the percent change in HR was associated with 5 min CO moving average significantly. Decreased trends in r-MSSD, SDNN, pNN50+1, LF, HF, and TP changes were found for increases with 5-60 min PM2.5-10 moving average exposure. Increases in 5-60 min PM1-2.5 moving average was associated with increases in r-MSSD, pNN50+1, and HF, but decreases in HR and LF/HF. Decreased changes in SDNN, LF, HF, and TP were associated with increased 5-60 min CO moving average. The changes of HRV indices varied with different size fractions of PM, as compared to fine PM, the PM2.5-10 had stronger effects on changing HRV. Conclusion All sized PM and CO exposures in public transits might induce significant changes of HRV indices in healthy young adults. The short-term effects of multi-sized PM and CO on some HRV indices last to 60 minutes.