| Summary: | 碩士 === 中原大學 === 生物醫學工程研究所 === 98 === Semiconductor quantum dots are attracted by its stability and tunable wavelengths, but containing toxic ions such as Cd2+, Pb2+ is a concerned issue for broad clinical application. To face on this problem, researchers have focused on developing new biocompatible materials with fluorescent properties. Fluorescent gold nanoclusters are becoming the alternative nanomaterials for nontoxic cellular labeling. Gold nanoclusters, consisting of several atoms, exhibit discrete electronic states and fluorescent properties. As a biocompatible materials, gold nanoclusters show a good candidate of novel fluorophore with many advantages, such as chemical stability, and general surface chemistry. In this study, synthesis of ultrafine fluorescent gold nanoclusters is included in this report. We focus on the issue how to efficiently label cells using specific carrier. we study the cell labeling efficiency of fluorescent gold nanoclusters using different forces (electric, megnetic). The nanoprobes design of fluorescent gold nanoclusters are also included. Specific staining of cells and nonspecific uptake by living cells are studied.
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