| Summary: | 碩士 === 中原大學 === 化學研究所 === 98 === Nuclear magnetic resonance spectroscopy (NMR) is a method for analyzing both small molecules and polymer chemical structure. It’s application includes among solid, liquid, and gel states samples. The pulse sequences may be classified as one-dimensional, two-dimensional, multi-dimensional . The samples for this study belongs to liquid state, and we used the function specific pulse sequence for this study. Pass through the J-coupling effect of chemical bond or the space dipolar interaction to speculate the bond status and geometric structure of the atomic nucleus in intramolecular.
Polymeric micelle for drug delivery system is a nanoparticles ball with core-shell structure. The polymeric micelle is composed of amphiphilic blocks. One of which is hydrophilic chain and the other is hydrophobic. When the concentration of amphiphilic polymer in aqueous solution is grater than the critical micelle concentration (CMC), the hydrophobic chain parts pass through the interaction of van der Waals force. By the way, the self-assembly structure of polymer nano micelles forms the copolymer of including inner hydrophobic core and outer shell hydrophilic. And then the nano micelles as drug carriers to control the manner and time of drug ease.
Use two kinds of hydrophilic polymers as the raw materials of synthetic drug carriers. In this experiment, use high-resolution liquid NMR to analyze the synthesis mechanism of HA-g-PCL and mPEG-g-PCL. First of all the used of hydrogen spectrum, carbon spectrum, Diffusion, COSY, editHSQC, HMBC, 1D-NOE and other experimental techniques to identify the purity of raw materials were suitable or not and confirmed the synthesized structure of intermediates and products.
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