| Summary: | 碩士 === 正修科技大學 === 機電工程研究所 === 98 === Osteoporosis is gradually becoming a number one invisible killer in this current aging society. Along with the extension of human life-span, osteoporosis turned into the second major epidemic disease only lower to cardiovascular diseases. Chemical medicine is the usual prescription but its side effect should not be overlooked. Therefore, some researchers discuss the treatment of osteoporosis by using physical stimulation.
Low capacity supersonic stimulation to the bone cell has been widely studied and in the stage of clinical application. But few report discussed about the best range of energy impulses to the bone cell. According to the literature, when supersonic energy act on the organism, the propagation of the sound wave will create heat, vibration, and massage effect to the tissue and provide both constructive and destructive physical therapy affects.
Osteoblast cell is a mononuclear cell which can cooperate with other cells to generate or rebuild osteoid of the skeleton. This research studies the culture of mice MC3T3 osteoblast cell in vitro, stimulate the growing cell with mechanical broad range of frequency (100 Hz to 10 MHz) with or without temperature factor and investigate the effect of different amplitude, repeated number of times, and excitation durations of the stimulation. The results show that several different parameters of the vibration excitation have the positive effect onto the osteoblast cell proliferation and the density of the bone is also increased remarkably.
|
|---|
