| Summary: | 碩士 === 中山醫學大學 === 口腔生物暨材料科學研究所 === 98 === The aim of this study was to develop bionic dense and porous scaffolds for bone repair. The gelatin solution was incorporated into calcium silicate powder to form the composition. The compressive strength, phase composition, and microstructure before and after immersion in simulated body fluid were evaluated, in addition to biocompatibility. The results of compressive strength showed that the dense and porous scaffold were 137 and 2.5 MPa, respectively, very close to those in the cortical and spongy bones. Regarding in vitro testing in simulated body fluid, the formation of apatite layer was apparent with increasing immersion time. The results of weight loss indicated that the gelatin additive increased biodegradation. This biocompatibility study indicated the composite scaffold significantly enhanced cell proliferation and differentiation. It is concluded that the biomimetic composites is a potential material for bone defect repair.
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